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Space Medicine Associates, Inc. Useful Information 2013-
   

Useful Information 2013-

Kim W et al. Spaceflight Promotes Biofilm Formation by Pseudomonas aeruginosa. PLOS ONE. 2013; 8(4): e62437.

Hollins H. Forgotten hardware: How to urinate in a spacesuit. Advan in Physio Edu. 2013; 37: 123-128. 

McGuire S, Sherman P, Profenna L et al. White matter hyperintensities on MRI in high-altitude U-2 pilots. Neurology 2013; 81: 729-735.

Pattarini JT, Blue RS, Aikins LT et al. Flat Spin and Negative Gz in High-Altitude Free Fall: Pathophysiology, Prevention, and Treatment. Aviat Space Environ Med 2013; 84: 961-970.

Blue RS, Hudson JC, Reiders MF et al. Medical Management of a Potentially Toxic Accidental Trialkylamine Ingestions During Spaceflight. Aviat Space Environ Med 2013; 84: 1100-1104.

Cavanagh PR, Rice AJ, Licata AA et al. A Novel Lunar Bed Rest Analogue. Aviat Space Environ Med 2013; 84: 1191-1195.

Collado A, Monfort V, Hainaut J-P et al. Personality Traits of People Attracted by Parabolic Flight. Aviat Space Environ Med 2014; 85:55-59.

Kim W, Tengra FK, Shong J et al. Effect of spaceflight on Pseudomonas aeruginosa final cell density is modulated by nutrient and oxygen availability. BMC Microbiology 2013,13:241. Available online at: http://www.biomedcentral.com/1471-2180/13/241.

Jennings R, Davis J, Logan J. Injectable promethazine use in spaceflight: space motion sickness and the evolution of treatment strategies (abstract 402). Aviat Space Environ Med 2013;84:395.                                                                         

Kuftas JM, Dulchavsky SA. Medical care in outer space: a useful paradigm for underserved regions on the planet. Surgery 2013;154:943-945.

Cucinotta FA, Kim MD, Chappell LJ, Huff JL. How safe is safe enough? Radiation risk for a human mission to Mars. PLoS One. 2013;9:e.74988.

Love SG, Reagan MG. Delayed voice communication. Acta Astronautica. 2013;91:89-95.

Scott-Conner CEH, Masys DR, Liverman CT, McCoy MA (eds.) Committee to Review NASA’s Evidence Reports on Human Health Risks; Board on Health Sciences Policy; Institute of Medicine. Review of NASA’s Evidence Reports on Human Health Risks. 2013 Letter Report (2014.) 

Ballard SB. The U.S. Commercial Air Tour Industry: A Review of Aviation Safety Concerns. Aviat Space Environ Med. 2014;85:160-166.

Garbino A, Blue RS, Pattarini JM et al. Physiological Monitoring and Analysis of a Manned Stratospheric Balloon Test Program. Aviat Space Environ Med. 2014;85:177-182.

Emanuelli M. Evolution of NASA Medical Kits: From Mercury to ISS. Space Safety Magazine. 2014. Available here: http://www.spacesafetymagazine.com/2014/03/17/evolution-medical-kits-mercury-iss/.

Carminati G. “Doctor, Doctor, Can I Go?” Medical Rules, Standards, and Guidelines for Suborbital Space. Space Safety Magazine. 2014. Available here: http://www.spacesafetymagazine.com/2014/03/28/doctor-doctor-medical-rules-standards-guidelines-suborbital-space/

May C, Borowski A, Martin D et al. Effect of Microgravity on Cardiac Shape: Comparison of Pre- and In-flight Data to Mathematical Modeling. Presented at: The American College of Cardiology 63rd Annual Scientific Session, 2014. Press release available here: http://www.eurekalert.org/pub_releases/2014-03/acoc-sfa032714.php

Institute of Medicine (IOM). Health Standards for Long Duration and Exploration Spaceflight: Ethics Principles, Responsibilities, and Decision Framework (2014). Available here: http://www.iom.edu/Reports/2014/Health-Standards-for-Long-Duration-and-Exploration-Spaceflight.aspx

Weerts A, Vanspauwen R, Fransen E et al. Space Motion Sickness Countermeasures: A Pharmacological Double-Blind, Placebo-Controlled Study. Aviat Space Environ Med 2014; 85: 638-644.

Drufi L, Grenon SM. Women’s Health in Spaceflight. Aviat Space Environ Med. 2014; 85: 645-652.   

Davis CM, DeCicco-Skinner KL, Roma PG, Hienz RD. Individual Differences in Attentional Deficits and Dopaminergic Protein Levels Following Exposure to Proton Radiation. Radiat Res. 2014 Mar;181:258-71.

Barger LK, Flynn-Evans EE, Kubey A et al. Prevalence of sleep deficiency and use of hypnotic drugs in astronauts before, during, and after spaceflight: an observational study. The Lancet Neurology 2014; 13: 904-912.

Zwart SR, Launius RD, Coen GK et al. Body Mass Changes During Long-Duration Spaceflight. Aviat Space Environ Med 2014; 85: 897-904.

Austin AW, Patterson SM, Ziegler MG, Mills PJ. Plasma Volume and Flight Duration Effects on Post Spaceflight Soluble Adhesion Molecules. Aviat Space Environ Med. 2014; 85: 912-918.

Ma H, Zhu Y, Xiao Y et al.  Biomechanical Sex Differences of Crewmembers During a Simulated Space Capsule Landing. Aviat Space Environ Med. 2014; 85: 925-929.

Somers JT, Gohmert DM, Brinkley JW. Spacecraft Occupant Protection Requirements: A Review of Recent Changes. Aviat Space Environ Med. 2014; 85: 940-948.

Guo Y, Li Y, Su L et al. Comparative genomic analysis of Klebsiella pneumonia (LCT-KP214) and a mutant straing (LCT-KP289) obtained after spaceflight. BMC Genomics. 2014; 15: 589. Available at: http://www.biomedcentral.com/1471-2164/15/589.

Chakraborty N, Gautam A, Muhie S et al. An intergrated omics analysis: impact of microgravity on host response to lipopolysaccharide in vitro. BMC Genomics 2014; 15: 659; published Aug 7, 2014.

Harris LR, Herpers R, Hofhammer T, Jenkin M. How Much Gravity Is Needed to Establish the Perpetual Upright? PLOS One. 2014; 9(9): e106207. Available at: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0106207.

Ma H, Zhu Y, Xiao Y et al. Biomechanical Sex Differences of Crewmembers During a Simulated Space Capsule Landing. Aviat Space Environ Med. 2014; 85: 925-929.

Scott-Conner CEH, Masys DR, Liverman CT, McCoy MA (eds.) Committee to Review NASA’s Evidence Reports on Human Health Risks; Board on Health Sciences Policy; Institute of Medicine. Review of NASA’s Evidence Reports on Human Health Risks. 2014 Letter Report (2015.) 

Tafforin C. Confinement vs. Isolation as Analogue Environments for Mars Missions from a Human Etiology Viewpoint. Aerosp Med Hum Perform. 2015; 86: 131-135.

Lerner DJ, Parmet AJ. Portable Radiography: A Reality and Necessity for ISS and Explorer-Class Missions. Aerosp Med Hum Perform. 2015; 86: 140-142.

Van Ombergen, Demertzi A, Tomilovskaya E et al. Cortical Reorganization in an Astronaut's Brain After Long-Duration Spaceflight. Brain Struct Func 2015; May 2015 (published online).

Levin DR, Blue RS, Castleberry TL, Vanderploeg JM. Tolerance of Centrifuge-Simulated Suborbital Spaceflight in Subjects with Implanted Insulin Pumps. Aerosp Med Hum Perform. 2015; 86: 407-409.

Blue RS, Reyes DP, Castleberry TL, Vanderploeg JM. Centrifuge-Simulated Suborbital Spaceflight in Subjects with Cardiac Implanted Devices. Aerosp Med Hum Perform. 2015; 86: 410-413.

Pool-Goudzwaard AL, Belavy DL, Hides JA, et al. Low Back Pain in Microgravity and Bed Rest Studies. Aerosp Med Hum Perform. 2015; 86: 541-547.

Bell ST, Brown SG, Abben DR, Outland NB. Team Composition Issues for Future Space Exploration: A Review and Directions for Future Research. Aerosp Med Hum Perform. 2015; 86: 548-556.

Michael AP, Marshall-Bowman K. Spaceflight-Induced Intracranial Hypertension. Aerosp Med Hum Perform. 2015; 86: 557-562.

Parihar VK, Allen B, Tran KK et al. What Happens to Your Brain on the Way to Mars. Space Advances 2015; 1: e1400256.

Wang Y, Wu R. Time Effects, Displacement, and Leadership Roles on a Lunar Space Station Analogue. Aerosp Med Hum Perform. 2015; 86: 819-823.

Prudhomme MB, Ropp LG, Sauer SW, LaVan JT. Aeromedical Risk Assessment of Pharmaceuticals Using Evidence-Based Medicine. Aerosp Med Hum Perform. 2015; 86: 824-829.

Wong JY. Ultra-Portable Solar-Powered 3D Printers for Onsite Manufacturing of Medical Resources. Aerosp Med Hum Perform. 2015; 86: 830-834.

Wong JY. On-Site 3D Printing of Functional Custom Mallet Splints for Mars Analogue Crewmembers. Aerosp Med Hum Perform. 2015; 86: 911-914.

Basner M, Savitt A, Moore TM et al. Development and Validation of the Cognition Test Battery for Spaceflight. Aerosp Med Hum Perform. 2015; 86: 942-952.

Blue RS, Blacher E, Castleberry TL, Vanderploeg JM. Centrifuge-Simulated Suborbital Spaceflight in a Subject with Cardiac Malformation. Aerosp Med Hum Perform. 2015; 86: 999-1003.

Wotring VE. Chemical Potency and Degradation Products of Medications Stored Over 550 Earth Days at the International Space Station. AAPS Journal. 2015; DOI: 10.1208/s12248-015-9834-5.

OIG. NASA's Efforts to Manage Health and Human Performance Risks for Space Exploration (Report No. IG-16-003). October 29, 2015. Available at: oig.nasa.gov.
 

Wotring VE. Medication Use by U.S. Crewmembers on the International Space Station. FASEB J. 2015; Nov; 29(11): 4417-4423.

Moskaleva N, Moysa A, Novikova S et al. Spaceflight Effects on Cytochrome P450 Content in Mouse Liver. PLOS One. 2015; 
DOI:10.1371/journal.pone.0142374.

Hurst VW, Peterson S, Garcia K et al. Concept of Operations Evaluation for Using Remote-Guidance Ultrasound for Exploration Spaceflight. Aerosp Med Hum Perform. 2015; 86:1034-1038.

Sawin C (ed.) Exercise Countermeasures: The First Decade on ISS. Aerosp Med Hum Perform. 2015; 86: Section II, Supplement.

Lawley J, Williams M, Petersen L et al. ICP During Daily Life in Healthy Adults: What Does Microgravity Add to the Mix? FASEB J. 2015 (April);29 (Suppl 1) 990.10.

Flynn-Evans EE, Barger LK, Kubey AA et al. Circadian misalignment affects sleep and medication use before and during spaceflight. NPJ Microgravity. doi:10.1038/npjmgrav.2015.19 (2016).

Scott-Conner CEH, Masys DR, Liverman CT, McCoy MA (eds.) Committee to Review NASA’s Evidence Reports on Human Health Risks; Board on Health Sciences Policy; Institute of Medicine. Review of NASA’s Evidence Reports on Human Health Risks. 2015 Letter Report (2016.) 

Lewin JJ, Choi EJ, Ling G. Pharmacy on demand: New Technologies to enable minaturized and mobile drug manufacturing. Am J Health-Syst Pharm. 2016; 73: 45-54.

Jonscher KR, Alfonso-Garcia A, Suhalim JL et al. Spaceflight Activates Lipotoxic Pathways in Mouse Liver. PLoSOne. 2016; 11(4):e0152877.doi:10.1371/ journal.pone.0152877. (correction published PLoSONE 11(5):e0155282. doi:10.1371/journal.pone.0155282).

Jain V, Wotring VE. Medically induced amenorrhea in female astronauts. NPJ Microgravity. 2016; 2, 16008; doi:10.1038/npjmgrav.2016.8, published online April 21, 2016.

The National Academies of Sciences, Engineering, and Medicine. 2016. Refinements to the Methods for Developing Spacecraft Exposure Guidelines. Washington, DC: The National Academies Press. doi: 10.17226/21888.

Wong JY. 3D Printing Applications for Space Missions. Aerosp Med Hum Perform. 2016; 87: 580-582.

Delp MD, Charvat JM, Limoli CL et al. Apollo Lunar Astronauts Show Higher Cardiovascular Disease Mortality: Possible Deep Space Radiation Effects on Vascular Endothelium. Scientific Reports. 2016;6:29901. DOI: 10.1038/srep29901.

Benjamin CA, Stowe RP, St. John L et al. Decreases in thymopoiesis of astronauts returning from spaceflight. JCI Insights. 2016; 1(12):e88787. doi:10.1172/jci.insight.88787.

Hartel W. Dental Care In Space. Quest. 2016;23:15-20.

Nicolas M, Bishop SL, Weiss K, Gaudino M. Social, Occupational, and Cultural Adaptation During a 12-Month Wintering in Antarctica. Aerosp Med Hum Perform. 2016; 87(9):781-789.

Wong JY, Pfahnl AC. 3D Printed Surgical Instruments Evaluated by a Simulated Crew of a Mars Mission. Aerosp Med Hum Perform. 2016; 87(9): 806-810.

Garbino A, Nusbaum DM, Buckland DM et al. Emergency Medical Considerations in a Space-Suited Patient. Aerosp Med Hum Perform. 2016; 87(11): 958-962.

Chang DG, Healey RM, Snyder AJ et al. Lumbar Spine Paraspinal Muscle and Intervertebral Disc Height Changes in Astronauts After Long-Duration Spaceflight on the International Space Station. Spine 2016; DOI: 10.1097/BRS.0000000000001873.

Alperin N, Bagci A, Lee S, Lam B. Role of Cerebrospinal Fluid in Spaceflight-Induced Visual Impairment and Ocular Changes. Radiological Society of North America 2016 Scientific Assembly and Annual Meeting, November 27- December 2, 2016, Chicago, IL. 

Koppelmanns V, Bloomberg JJ, Mulavara AP, Seidler RD. Brain stuctural plasticity with spaceflight. npj Microgravity 2016;
 2:2 ; doi:10.1038/s41526-016-0001-9. 

Nicogossian A, Williams RS, Huntoon CL et al (eds). Space Physiology and Medicine: From Evidence to Practice, 4th ed. 2016; Springer Science + Business Media.

Scott-Conner CEH, Masys DR, Liverman CT, McCoy MA (eds.) Committee to Review NASA’s Evidence Reports on Human Health Risks; Board on Health Sciences Policy; Institute of Medicine. Review of NASA’s Evidence Reports on Human Health Risks. 2016 Letter Report (2017.) 

Golding JF, Paillard AC, Normand H et al. Prevalence, Predictors, and Prevention of Motion Sickness in Zero-G Parabolic Flights. Aerosp Med and Hum Perf. 2017; 88 (1): 3-8.

Marshall-Goebel K, Mulder E, Bershad E, et al. Intracranial and Intraocular Pressure During Various Degrees of Head-Down Tilt. Aerosp Med Hum Perf. 2017; 88(1): 10-16.

Campbell MR. The Apollo 1 Fire. Aerosp Med Hum Perf. 2017; 88(1): 71-72.

Lawley JS, Petersen LG, Howden EJ et al. Effect of gravity and microgravity on intracranial pressure. Journal of Physiology 2017 (accepted article- DOI: 10.1113/JP273557.) 

Reynolds RJ, Day SM. Mortality Due to Cardiovascular Disease Among Apollo Lunar Astronauts. Aerosp Med Hum Perf. 2017; 88 (5): 492-496.

Ade CJ, Broxterman RM, Moore AD, Barstow TJ. Decreases in maximal oxygen uptake following long-duration spaceflight: Role of convective and diffusive O2 transport mechanisms. J App Physiol 2017; 122:968-975.

Wakayama S, Kamada Y, Yamanaka K et al. Healthy offspring from freeze-dried mouse spermatozoa held on the International Space Station for 9 months. Proc Natl Acad Sci. doi/10.1073/pnas 1701425114 (2017).

Blue RS, Bonato F, Seaton K et al. The Effects of Training on Anxiety and Task Performance in Simulated Suborbital Spaceflight. Aerosp Med Hum Perform. 2017; 88(7): 641-650.

McLaughlin MF, Donoviel DB, Jones JA. Novel Indications for Commonly Used Medications as Radiation Protectants in Spaceflight. Aerosp Med Hum Perform. 2017; 88(7): 665-676.

Zwart S, Gibson CR, Gregory JF et al. Astronaut Ophthalmic Syndrome. FASEB J. 2017; 31 (published online May 2017).

Larina IM, Percy AJ, Yang J et al. Protein Expression Changes Caused by Spaceflight as Measured for 18 Russian Cosmonauts. Nature Sci Reports. 2017; 7:8142. DOI:
10.1038/s41598-017-08432-w.

Kunz H, Quirarte H, Simpson RH et al. Alterations in hematologic indices during long-duration spaceflight. BMC Hematology. 2017; 17 (1) DOI: 10.1186/s12878-017-0083-y.

Zea L, Larsen M, Estante F et al. Phenotypic changes exhibited by E. coli cultured in space. Front Microbiol. 2017; DOI: 10.3389/fmicb.2017.01598.

Suresh R, Blue RS, Mathers C, Castleberry TL, Vanderploeg JM. Sustained 
Accelerated Idioventricular Rhythm in a Centrifuge-Simulated Suborbital Spaceflight. Aerosp Med Hum Perform. 2017 Aug 1;88(8):789-793. 

Law J, Young M, Alexander D et al. Carbon Dioxide Physiological Training at NASA. Aerosp Med Hum Perform. 2017; 88 (10):897-902.

Arbielle P, Provost R, Zuj K. Carotid and Femoral Arterial Wall Distensibility During Long-Duration Spaceflight. Aerosp Med Hum Perform. 2017; 88 (10): 924-930.

Moore TM, Basner M, Nasrini J et al. Validation of the Cognition Test Battery for Spaceflight in a Sample of Highly Educated Adults. Aerosp Med Hum Perform. 2017; 88 (10): 937-946.

Suresh R, Blue RS, Mathers CH et al. Dysrhythmias in Laypersons During Centrifuge-Simulated Suborbital Spaceflight. Aerosp Med Hum Perform. 2017; 88 (10): 1008-1015.

Friedman E, Bui B. A Psychiatric Formulary for Long-Duration Spaceflight. Aerosp Med Hum Perform. 2017; 88 (10): 1024-1033.

Campbell MR. The Medilab Mir Module. Aerosp Med Hum Perform. 2017; 88 (10): 1056-1057.

Roberts DR, Albrecht MH, Collins HR et al. Effects of Spaceflight on Astronaut Brain Structure as Indicated on MRI. New Engl J Med. 2017; 377: 1746-1753.

Ushakov IB, Voronkov YI, Bukhtiyarov IV et al. A Cohort Mortality Study Among Soviet and Russian Cosmonauts, 1961-2014. Aerosp Med Hum Perform. 2017; 88 (12): 1060-1065.

Wu D, Zheng C, Wu J et al. Molecular Biological Effects of Weightlessness and Hypergravity on Intervertebral Disc Degeneration. Aerosp Med Hum Perform. 2017; 88 (12): 1123-1128.

Stahn AC, Werner A, Opatz O et al. Increased core body temperature in astronauts during long-duration space missions. Nature Sci Rep. 2017; 7:16180, doi: 10.1038/s41598-017-15560-w.

Reyes DP, Brinley AA, Blue RS, Gruschkus SK, Allen AT, Parazynski SE. Clinical Herpes Zoster in Antarctica as a Model for Spaceflight. Aerosp Med Hum Perform. 2017 Aug 1;88(8):784-788. 

Patel N, Pass A, Mason S. Optical Coherence Tomography Analysis of the Optic Nerve Head and Surrounding Structures in Long-Duration International Space Station Astronauts. JAMA Opthalmol. Published online January 11, 2018. doi: 10.1001/jamaopthalmol.2017.6226.

Scott-Conner CEH, Masys DR, Liverman CT (eds.) Committee to Review NASA’s Evidence Reports on Human Health Risks; Board on Health Sciences Policy; Institute of Medicine. Review of NASA’s Evidence Reports on Human Health Risks. 2017 Letter Report (2018.)

Antonsen EL, Mulcahy RA, Rubin D et al. Prototype Development of a Tradespace Analysis Tool for Spaceflight Medical Resources. Aerosp Med Hum Perform. 2018; 89(2): 108-114.

Johansen BD, Blue RS, Castleberry TL et al. Point-of-Care Ultrasound for Pulmonary Concerns in Remote Spaceflight Triage Environments. Aerosp Med Hum Perform. 2018; 89(2): 122-129.

Komorowski M, Fleming S, Mawkin M, Hinkelbein J. Anaesthesia in austere environments: literature review and considerations for future space exploration missions. NPJ Microgravity 2018; 4:5; doi: 10.1038/s41526-018-0039-y.

Beheshti A, Cekanaviciute E, Smith DJ, Costes SV. Global transcriptomic analysis suggests carbon dioxide as an environmental stressor in spaceflight: A systems biology GeneLab case study. Nature Scientific Reports.2018;8:4191.


Carpentier WR, Charles JB, Shelhamer M et al. Biomedical findings from NASA's Project Mercury: A case series. NPJ Microgravity. 2018; 4:6.

Szocik K, Marques RE, Abood S et al. Biological and social challenges of human reproduction on a long-term Mars base. Futures. 2018 June; 100: 56-62. 

Buckey JC, Phillips SD, Andersen AP, et al. Microgravity-induced ocular changes are related to body weight. American J Physiology- Regulatory, Integrative and Comparative Physiology. 2018 May (published ahead of print). 

Kumar S, Suman S, Fornace AJ, Datta K. Space radiation triggers persistent stress response, increases senescent signalling, and decreases cell migration in mouse intestine. PNAS. 2018 October 1 (published ahead of print).